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Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.

Dosage and Administration

Sildenafil is available in 25mg, 50mg, and 100mg strengths.

  • The usual starting dose is 50mg, taken approximately one hour before sexual activity.
  • Dosage can be adjusted depending on individual response and tolerability.
  • Take only one tablet in 24 hours, with or without food.
  • Avoid grapefruit juice, as it can increase the risk of side effects.
  • A high-fat meal may delay onset of action.

Effectiveness

Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.

Side Effects

Common side effects include:

  • Headache
  • Flushing
  • Nasal congestion
  • Indigestion

Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.

Contraindications

Sildenafil should not be used by those:

  • Taking nitrates for chest pain
  • With severe heart or liver conditions
  • Under 18 years of age
  • With certain medication interactions (e.g. alpha-blockers, antifungals, antibiotics)

Interactions

Inform your doctor of all medications and supplements before use. Interactions may occur with:

  • Nitrates
  • Alpha-blockers
  • Some antibiotics and antifungal medicines

Alcohol and Heart Conditions

Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.

Availability and Cost

Sildenafil is available by prescription only in the UK.

  • Generic versions are more affordable than branded Viagra.
  • Supplied by licensed UK pharmacies such as Online Chemist.
  • Avoid counterfeit products from unregulated websites.

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Erectile dysfunction

Erectile dysfunction (ED) affects approximately 30 million men worldwide, and is the most common male sexual disorder. ED is caused by insufficient blood flow to the penile area, causing blood vessels to tighten and the penis to enlarge. In men with ED, blood flow is decreased, causing the penis to enlarge. The exact cause of ED is still unknown. It is generally thought that many factors may contribute to ED, including stress, medications, lifestyle factors, and environmental factors.

The most common cause of ED in men is non-specific or genetic factors. Non-specific causes include certain medications, hormonal changes, lifestyle factors, and environmental factors. Certain drugs can increase the blood flow to the penis and increase the risk of ED. These drugs include selective phosphodiesterase 5 (PDE5) inhibitors such as Viagra and Cialis. Sildenafil (Viagra) and tadalafil (Cialis) are the most frequently prescribed ED drugs. These medications increase blood flow to the penis, making it easier for men to achieve and maintain an erection.

How ED affects your penis

Erectile dysfunction is most common in men who have sex. The causes of ED may include:

  • Low blood pressure
  • Medications and hormonal changes
  • Poor diet and alcohol intake
  • Smoking and excessive alcohol consumption
  • Poor exercise and poor diet
  • Drugs, alcohol, and medications

Medications that increase blood flow to the penis

Many drugs and medications can increase blood flow to the penis. These drugs include:

  • Nitroglycerin
  • Nitroprusside
  • Amiodarone
  • Amlodipine
  • Alendronic acid
  • Clonidine
  • Eprosartan
  • Fluorouracil

Certain medications can increase the blood flow to the penis. These medications include:

  • Amifostine
  • Alfuzosin
  • Azilsartan
  • Cimetidine
  • Clomipramine
  • Ipratropium
  • Nefazodone

Many medications and medications can increase blood flow to the penis, including:

  • Atenolol
  • Lisinopril
  • Phentermine
  • St. John's wort

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        • Your Doctor has advised you to avoid activity because of a problem with your heart or blood vessels
        • You have a heart problem such as a recent heart attack or stroke (within the last 6 months), Chest pain (Angina) or severe Heart failure (reduced pumping capacity of the heart)
        • You have a liver problem
        • You have low blood pressure (below 90/50 mmHg) which can cause symptoms such as tiredness, dizziness, light-headedness, feeling sick, clammy skin, depression, loss of consciousness, or blurry vision
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